Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6

Thibault Viennet, Maolu Yin, Abhilash Jayaraj, Woojin Kim, Zhen-Yu J Sun, Yuko Fujiwara, Kevin Zhang, Davide Seruggia, Hyuk-Soo Seo, Sirano Dhe-Paganon, Stuart H Orkin, Haribabu Arthanari.
Structure. 2024 Oct 12:S0969-2126(24)00422-2. doi: 10.1016/j.str.2024.09.022. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/39423807/

CRISPR-CLEAR: Nucleotide-Resolution Mapping of Regulatory Elements via Allelic Readout of Tiled Base Editing

Basheer Becerra, Sandra Wittibschlager, Zain M Patel, Ana P Kutschat, Justin Delano, Eric Che, Anzhelika Karjalainen, Ting Wu, Marlena Starrs, Martin Jankowiak, Daniel E Bauer, Davide Seruggia, Luca Pinello.
bioRxiv [Preprint]. 2024 Sep 9:2024.09.09.612085. doi: 10.1101/2024.09.09.612085.
Abstract: https://pubmed.ncbi.nlm.nih.gov/39314441/

The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity

Cristiano De Sá Fernandes, Philipp Novoszel, Tommaso Gastaldi, Dana Krauß, Magdalena Lang, Ramona Rica, Ana P Kutschat, Martin Holcmann, Wilfried Ellmeier, Davide Seruggia, Herbert Strobl, Maria Sibilia.
Cell Rep. 2024 Jun 25;43(6):114308. doi: 10.1016/j.celrep.2024.114308. Epub 2024 Jun 2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38829740/

Role of PDGFRA⁺ cells and a CD55⁺ PDGFRA^Lo fraction in the gastric mesenchymal niche

Elisa Manieri, Guodong Tie, Ermanno Malagola, Davide Seruggia, Shariq Madha, Adrianna Maglieri, Kun Huang, Yuko Fujiwara, Kevin Zhang, Stuart H Orkin, Timothy C Wang, Ruiyang He, Neil McCarthy, Ramesh A Shivdasani.
Nat Commun. 2023 Dec 2;14(1):7978. doi: 10.1038/s41467-023-43619-y.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38042929/

In vivo CRISPR/Cas9 screening identifies Pbrm1 as a regulator of myeloid leukemia development in mice

Bin E Li, Grace Y Li, Wenqing Cai, Qian Zhu, Davide Seruggia, Yuko Fujiwara, Christopher R Vakoc, Stuart H Orkin.
Blood Adv. 2023 Sep 26;7(18):5281-5293. doi: 10.1182/bloodadvances.2022009455.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37428871/

Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells

Stuti Mehta, Altantsetseg Buyanbat, Yan Kai, Ozge Karayel, Seth Raphael Goldman, Davide Seruggia, Kevin Zhang, Yuko Fujiwara, Katherine A Donovan, Qian Zhu, Huan Yang, Behnam Nabet, Nathanael S Gray, Matthias Mann, Eric S Fischer, Karen Adelman, Stuart H Orkin.
Cell Chem Biol. 2022 Aug 18;29(8):1273-1287.e8. doi: 10.1016/j.chembiol.2022.06.007. Epub 2022 Jul 14.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35839780/