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Solgate Co-Founders (from left to right): Georg Winter, Stefan Kubicek, Ariel Bensimon, Giulio Superti-Furga, Gaia Novarino (© Thomas Zauner / IST Austria).

Solgate closes its first financing round with IST cube and private investors

Joint CeMM-IST Austria start-up develops new class of drugs targeting solute carrier proteins

Solgate GmbH, an Austrian early-stage biotech company, announces the completion of its first financing round from a group of venture and private investors.

Solgate was incorporated in 2020 by a high-profile founding team and with intellectual property from the leading research institutions CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, and IST Austria (Institute of Science and Technology Austria), with support from the Austrian business agency (AWS). The company applies methods from chemistry, cell biology,…

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New research groups at CeMM: Barbara Maier, Georg Busslinger and Davide Seruggia

At the beginning of 2021, Barbara Maier, Georg Busslinger and Davide Seruggia joined CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences. Barbara Maier as Principal Investigator at CeMM, Georg Busslinger and Davide Seruggia as CeMM Adjunct Principal Investigators, Georg having his main affiliation at the Division of Gastroenterology and Hepatology of the Medical University of Vienna and Davide at St. Anna Children’s Cancer Research Institute. The three researchers strengthen CeMM’s expertise in the fields of tumor immunology, gastrointestinal biology and pediatric leukemia biology.

Barbara Maier studied…

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Artistic representation of the BAF complex interacting with DNA and nucleosomes (© CeMM)

Inhibition of the BAF complex causes rapid loss of DNA accessibility

When human cells have to adapt due to a wide variety of external influences, the BAF complex plays a central role because it controls the accessibility of the DNA and thus the information stored in it. In every fifth human cancer, a mutation is found in one of the BAF complex genes. Scientists from the research group of Principal Investigator Stefan Kubicek at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences have now investigated this complex in more detail using novel techniques and were able to show how quickly changes in the BAF complex genes influence the accessibility of DNA. The study has now been…

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5th RESOLUTE Consortium Meeting (27-29 January 2021)

On 27 - 29 January 2021, the 5th RESOLUTE Consortium Meeting took place virtually. RESOLUTE is a public-private partnership, funded with a grant from the Innovative Medicines Initiative (IMI) and coordinated by CeMM and Pfizer, with 13 partners from academia and industry. Its mission is to increase the study of solute carriers for medical research and potential drug development, and it strives to become a reference hub for SLC research and open knowledge worldwide.

This year again virtually, more than 60 RESOLUTE partners joined the online event entitled “Abbey Road Studios” with a focus on different music genres. On the first day, featuring…

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The next-generation sequencing and data analysis pipeline (© Illustration: Zsofia Keszei, Thomas Winkler-Penz, Andreas Bergthaler / CeMM).

How does next-generation sequencing work and how long does it take?

An interdisciplinary team led by Andreas Bergthaler and Christoph Bock at CeMM is sequencing around 400 virus samples from Austria per week for the Austrian Agency for Health and Food Safety (AGES). The goal is to look for specific SARS-CoV-2 variants with multiple spike protein mutations, and to learn more about the molecular understanding of the COVID-19 pandemic and the causative pathogen.

The enclosed illustration demonstrates the standard next-generation sequencing and data analysis pipeline for SARS-CoV-2 viral genomes which takes approximately seven days. The aim is to obtain viral full-length genomes with low frequency variants at…

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Watercolour portrait of Denise P. Barlow (1950-2017) by artist Lisl Spurny-Schwarzmüller
© CeMM/Klaus Pichler

Denise P. Barlow Award Call is open

The second call of the Denise P. Barlow Award for best thesis on biological mechanisms is now open. Denise was a CeMM Principal Investigator for ten years until her passing and was also associated with other three research institutions in Vienna: as a group leader in IMP, a professor in Max Perutz Labs and she was also provided with laboratory space at IMBA.

These four institutions decided to launch a yearly academic talent award in Denise’s name, highlighting her figure as a formidable researcher who inspired the whole molecular biology community in Austria and beyond. This award aims at promoting the academic career of young scientists,…

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Illustration of SARS CoV-2 Sequencing (© CeMM)

Mutational Dynamics of SARS-CoV-2 in Austria: UK and South Africa variants found in Austria

Over the last few weeks, the United Kingdom and South Africa have faced a rapid increase in COVID-19 cases leading to enhanced epidemiological and virological investigations. Analysis of viral genome sequence data identified a sizeable proportion of cases belonging to new phylogenetic clusters. The new SARS-CoV-2 variants are defined by nonsynonymous, several of which are found in the viral spike protein, and still of uncertain functional significance. While it is known that viruses constantly change through mutation, and seldom does it lead to biological changes, the variants now increasingly observed in the UK and South Africa may be…

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Christoph Bock becomes Professor of Medical Informatics at MedUni Vienna

Christoph Bock has been appointed as professor of medical informatics at the Medical University of Vienna and head of the Institute for Artificial Intelligence and Decision Support at CeMSIIS, starting 1 January 2021. The bioinformatician and genome researcher joins MedUni Vienna from the neighboring CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. He will continue to lead his research group at CeMM, complementary to the new tasks at MedUni Vienna.

As a trained computer scientist with a broad range of interests, Christoph Bock has been working at the interface between biology, medicine, and computer science…

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The CeMM Directors Giulio Superti-Furga and Anita Ender

CeMM supports the Seitenwechsel initiative

Seitenwechsel is a spin-off of the MEGA Education Foundation, which promotes innovative educational initiatives in the areas of chance/fairness and business competence/life skills to support Austrian talent. Seitenwechsel is looking for committed and determined teachers who would like to take the opportunity to deepen their experience by working in a company for a year. On the second year, they will bring impulses from their professional experience back into their schools and implement these new fresh approaches in their teaching to better prepare the pupils for a successful start into their own career.

Continuing education, gaining…

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Season greetings

CeMM continues to be a place where biomedical research excellence goes hand in hand with social responsibility and innovation. With our two new spin-off companies Proxygen and Solgate, with our project on the “Mutational Dynamics of SARS-CoV-2 in Austria”, where CeMM has contributed the majority (>98%) of SARS-CoV-2 virus genomes from Austria to the public database GISAID. With many scientific publications and grants in 2020, resulting from our main research focus on immune disorders and infections, cancer and metabolic disorders, we are happy to look back on another successful year of advancing science. We also wish to thank all our…

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