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Year
Paper
2024

Protein binder toolbox for studies of solute carrier transporters

 Zuzana Gelová, Alvaro Ingles-Prieto, Tina Bohstedt, Fabian Frommelt, Gamma Chi, Yung-Ning Chang, Julio Garcia, Gernot Wolf, Lucia Azzollini, Sara Tremolada, Andreea Scacioc, Jesper S Hansen, Iciar Serrano, Aida Droce, Jenifer Cuesta Bernal, Nicola A Burgess-Brown, Elisabeth P Carpenter, Katharina L Dürr, Peter Kristensen, Eric R Geertsma, Saša Štefanić, Lia Scarabottolo, Tabea Wiedmer, Vera Puetter, David B Sauer, Giulio Superti-Furga.
J Mol Biol. 2024 Jun 13:168665. doi: 10.1016/j.jmb.2024.168665. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38878854/
2024

Development of a live cell assay for the zinc transporter ZnT8

 Lucia Azzollini, Dolores Del Prete, Gernot Wolf, Christoph Klimek, Mattia Saggioro, Fernanda Ricci, Eirini Christodoulaki, Tabea Wiedmer, Alvaro Ingles-Prieto, Giulio Superti-Furga, Lia Scarabottolo.
SLAS Discov. 2024 Jun 5;29(5):100166. doi: 10.1016/j.slasd.2024.100166. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38848895/
2024

AspSnFR: A genetically encoded biosensor for real-time monitoring of aspartate in live cells

 Lars Hellweg, Martin Pfeifer, Miroslaw Tarnawski, Shao Thing-Teoh, Lena Chang, Andrea Bergner, Jana Kress, Julien Hiblot, Tabea Wiedmer, Giulio Superti-Furga, Jürgen Reinhardt, Kai Johnsson, Philipp Leippe.
Cell Chem Biol. 2024 May 20:S2451-9456(24)00179-X. doi: 10.1016/j.chembiol.2024.05.002. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38806058/
2024

Image-based quantification of mitochondrial iron uptake via Mitoferrin-2

 Marcello Polesel, Mattheus H E Wildschut, Cédric Doucerain, Michael Kuhn, Anna Flace, Leandro Sá Zanetti, Anna-Lena Steck, Maria Wilhelm, Alvaro Ingles-Prieto, Tabea Wiedmer, Giulio Superti-Furga, Vania Manolova, Franz Dürrenberger.
Mitochondrion. 2024 Apr 30;78:101889. doi: 10.1016/j.mito.2024.101889. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38692382/
2024

Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells

 Fabian Offensperger, Gary Tin, Miquel Duran-Frigola, Elisa Hahn, Sarah Dobner, Christopher W Am Ende, Joseph W Strohbach, Andrea Rukavina, Vincenth Brennsteiner, Kevin Ogilvie, Nara Marella, Katharina Kladnik, Rodolfo Ciuffa, Jaimeen D Majmudar, S Denise Field, Ariel Bensimon, Luca Ferrari, Evandro Ferrada, Amanda Ng, Zhechun Zhang, Gianluca Degliesposti, Andras Boeszoermenyi, Sascha Martens, Robert Stanton, André C Müller, J Thomas Hannich, David Hepworth, Giulio Superti-Furga, Stefan Kubicek, Monica Schenone, Georg E Winter.
Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38662832/
2024

ProteoMutaMetrics: machine learning approaches for solute carrier family 6 mutation pathogenicity prediction

 Jiahui Huang, Tanja Osthushenrich, Aidan MacNamara, Anders Mälarstig, Silvia Brocchetti, Samuel Bradberry, Lia Scarabottolo, Evandro Ferrada, Sergey Sosnin, Daniela Digles, Giulio Superti-Furga, Gerhard F Ecker.
RSC Adv. 2024 Apr 22;14(19):13083-13094. doi: 10.1039/d4ra00748d. eCollection 2024 Apr 22.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38655474/
2024

EU-LIFE charter of independent life science research institutes

 Giulio Superti-Furga, Marta Agostinho, Jo Bury, Simon Cook, Christine Durinx, Anita Ender, Henri van Luenen, Anders H Lund, René H Medema, Marta Miączyńska, Dorthe Nickel, Pier Giuseppe Pelicci, Alain Puisieux, Samuli Ripatti, Maike Sander, Dirk Schubeler, Luis Serrano, Thomas Sommer, Katrine Sonne-Hansen, Pavel Tomančák, Joan Vives, John Vontas, Mónica Bettencourt-Dias.
FEBS Lett. 2024 Apr;598(7):719-724. doi: 10.1002/1873-3468.14855. Epub 2024 Mar 21.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38514456/
2024

Mechanical Actuation of Organoids in Synthetic Microenvironments

 Francesca Sgualdino, Lorenzo Mattolini, Brian Daza Jimenez, Kieran Patrick, Abdel Rahman Abdel Fattah, Adrian Ranga.
Methods Mol Biol. 2024;2764:225-245. doi: 10.1007/978-1-0716-3674-9_15.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38393598/
2023

Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling

 Amanda Ng, Fabian Offensperger, Jose A Cisneros, Natalie S Scholes, Monika Malik, Ludovica Villanti, Andrea Rukavina, Evandro Ferrada, J Thomas Hannich, Anna Koren, Stefan Kubicek, Giulio Superti-Furga, Georg E Winter.
ACS Chem Biol. 2023 Dec 15;18(12):2464-2473. doi: 10.1021/acschembio.3c00598. Epub 2023 Nov 21.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38098458/
2023

Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8

 Evandro Ferrada, Tabea Wiedmer, Wen-An Wang, Fabian Frommelt, Barbara Steurer, Christoph Klimek, Sabrina Lindinger, Tanja Osthushenrich, Andrea Garofoli, Silvia Brocchetti, Samuel Bradberry, Jiahui Huang, Aidan MacNamara, Lia Scarabottolo, Gerhard F Ecker, Anders Malarstig, Giulio Superti-Furga.
J Mol Biol. 2024 Jan 15;436(2):168383. doi: 10.1016/j.jmb.2023.168383. Epub 2023 Dec 7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38070861/
2023

Using an embryo specific promoter to modify iron distribution pattern in Arabidopsis

 Marlene Fuenzalida, María Isabel Gómez, Evandro Ferrada, Cristóbal Díaz, Viviana Escudero, Manuel González-Guerrero, Xavier Jordana, Hannetz Roschzttardtz.
Plant Sci. 2024 Feb;339:111931. doi: 10.1016/j.plantsci.2023.111931. Epub 2023 Nov 27.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38030036/
2023

A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity

 Andras Boeszoermenyi, Léa Bernaleau, Xudong Chen, Felix Kartnig, Min Xie, Haobo Zhang, Sensen Zhang, Maeva Delacrétaz, Anna Koren, Ann-Katrin Hopp, Vojtech Dvorak, Stefan Kubicek, Daniel Aletaha, Maojun Yang, Manuele Rebsamen, Leonhard X Heinz, Giulio Superti-Furga.
Nat Commun. 2023 Oct 20;14(1):6626. doi: 10.1038/s41467-023-42070-3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37863876/
2023

Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling

 Xudong Chen, Min Xie, Sensen Zhang, Marta Monguió-Tortajada, Jian Yin, Chang Liu, Youqi Zhang, Maeva Delacrétaz, Mingyue Song, Yixue Wang, Lin Dong, Qiang Ding, Boda Zhou, Xiaolin Tian, Haiteng Deng, Lina Xu, Xiaohui Liu, Zi Yang, Qing Chang, Jie Na, Wenwen Zeng, Giulio Superti-Furga, Manuele Rebsamen, Maojun Yang.
Nat Commun. 2023 Oct 20;14(1):6627. doi: 10.1038/s41467-023-42210-9.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37863913/
2023

Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA repair by increasing nuclear NAD+ levels

 Anka Güldenpfennig, Ann-Katrin Hopp, Lukas Muskalla, Patrick Manetsch, Fabio Raith, Lars Hellweg, Cyril Dördelmann, Deena M Leslie Pedrioli, Kai Johnsson, Giulio Superti-Furga, Michael O Hottiger.
Nucleic Acids Res. 2023 Sep 22;51(17):9248-9265. doi: 10.1093/nar/gkad659.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37587695/
2023

Structural and functional annotation of solute carrier transporters: implication for drug discovery

 Vojtech Dvorak, Giulio Superti-Furga.
Expert Opin Drug Discov. 2023 Jul-Dec;18(10):1099-1115. doi: 10.1080/17460441.2023.2244760. Epub 2023 Aug 10.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37563933/
2023

Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors

 Vojtech Dvorak, Andrea Casiraghi, Claire Colas, Anna Koren, Tatjana Tomek, Fabian Offensperger, Andrea Rukavina, Gary Tin, Elisa Hahn, Sarah Dobner, Fabian Frommelt, Andras Boeszoermenyi, Viktoriia Bernada, J Thomas Hannich, Gerhard F Ecker, Georg E Winter, Stefan Kubicek, Giulio Superti-Furga.
Cell Chem Biol. 2023 Aug 17;30(8):953-964.e9. doi: 10.1016/j.chembiol.2023.06.029. Epub 2023 Jul 28.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37516113/
2023

LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma

 Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, Florencio Porto Freitas, Felix C E Vogel, Julianna Patricia Varga, Jasmin Batani, Christoph Bartenhagen, Werner Schmitz, Gabriele Büchel, Bernhard Michalke, Jashuo Zheng, Svenja Meierjohann, Enrico Girardi, Elisa Espinet, Andrés F Flórez, Ancely Ferreira Dos Santos, Nesrine Aroua, Tasneem Cheytan, Julie Haenlin, Lisa Schlicker, Thamara N Xavier da Silva, Adriana Przybylla, Petra Zeisberger, Giulio Superti-Furga, Martin Eilers, Marcus Conrad, Marietta Fabiano, Ulrich Schweizer, Matthias Fischer, Almut Schulze, Andreas Trumpp, José Pedro Friedmann Angeli.
EMBO Mol Med. 2023 Aug 7;15(8):e18014. doi: 10.15252/emmm.202318014. Epub 2023 Jul 12.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37435859/
2023

Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis

 Maximilian Kugler, Mirjam Dellinger, Felix Kartnig, Lena Müller, Teresa Preglej, Leonhard X Heinz, Elisabeth Simader, Lisa Göschl, Stephan E Puchner, Sebastian Weiss, Lisa E Shaw, Matthias Farlik, Wolfgang Weninger, Giulio Superti-Furga, Josef S Smolen, Guenter Steiner, Daniel Aletaha, Hans P Kiener, Myles J Lewis, Costantino Pitzalis, Anela Tosevska, Thomas Karonitsch, Michael Bonelli.
Ann Rheum Dis. 2023 Sep;82(9):1142-1152. doi: 10.1136/ard-2022-223396. Epub 2023 Jun 21.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37344156/
2023

Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing

 Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Ferenc Torma, Michael Orthofer, Rebecca Yarwood, Leonhard X Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya Al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J F Cronin, Maria Novatchkova, Anoop Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey V Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Eric Rullman, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S Chamberlain, Marica Bakovic, Siddharth Banka, Josef M Penninger.
Nat Metab. 2023 Apr;5(4):711. doi: 10.1038/s42255-023-00791-1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37024756/
2023

PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing

 Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Ferenc Torma, Michael Orthofer, Rebecca Yarwood, Leonhard X Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya Al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J F Cronin, Maria Novatchkova, Anoop Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey V Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Eric Rullman, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S Chamberlain, Marica Bakovic, Siddharth Banka, Josef M Penninger.
Nat Metab. 2023 Mar;5(3):495-515. doi: 10.1038/s42255-023-00766-2. Epub 2023 Mar 20.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36941451/
2023

A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery

 Patrick Essletzbichler, Vitaly Sedlyarov, Fabian Frommelt, Didier Soulat, Leonhard X Heinz, Adrijana Stefanovic, Benedikt Neumayer, Giulio Superti-Furga.
Life Sci Alliance. 2023 Feb 1;6(4):e202201715. doi: 10.26508/lsa.202201715. Print 2023 Apr.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36725334/
2022

Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity

 Marcello Polesel, Alvaro Ingles-Prieto, Eirini Christodoulaki, Evandro Ferrada, Cédric Doucerain, Patrick Altermatt, Michelle Knecht, Michael Kuhn, Anna-Lena Steck, Maria Wilhelm, Vania Manolova.
Biometals. 2023 Feb;36(1):227-237. doi: 10.1007/s10534-022-00474-6. Epub 2022 Dec 1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36454509/
2022

A structure and evolutionary-based classification of solute carriers

 Evandro Ferrada, Giulio Superti-Furga.
iScience. 2022 Sep 8;25(10):105096. doi: 10.1016/j.isci.2022.105096. eCollection 2022 Oct 21.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36164651/
2022

Deep Morphology Learning Enhances Ex Vivo Drug Profiling-Based Precision Medicine

 Tim Heinemann, Christoph Kornauth, Yannik Severin, Gregory I Vladimer, Tea Pemovska, Emir Hadzijusufovic, Hermine Agis, Maria-Theresa Krauth, Wolfgang R Sperr, Peter Valent, Ulrich Jäger, Ingrid Simonitsch-Klupp, Giulio Superti-Furga, Philipp B Staber, Berend Snijder.
Blood Cancer Discov. 2022 Nov 2;3(6):502-515. doi: 10.1158/2643-3230.BCD-21-0219.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36125297/
2022

Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

 Manuele Rebsamen, Enrico Girardi, Vitaly Sedlyarov, Stefania Scorzoni, Konstantinos Papakostas, Manuela Vollert, Justyna Konecka, Bettina Guertl, Kristaps Klavins, Tabea Wiedmer, Giulio Superti-Furga.
Life Sci Alliance. 2022 Sep 16;5(11):e202201404. doi: 10.26508/lsa.202201404. Print 2022 Nov.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36114003/
2022

Accelerating SLC Transporter Research: Streamlining Knowledge and Validated Tools

 Tabea Wiedmer, Alvaro Ingles-Prieto, Ulrich Goldmann, Claire M Steppan, Giulio Superti-Furga, RESOLUTE, REsolution consortia.
Clin Pharmacol Ther. 2022 Sep;112(3):439-442. doi: 10.1002/cpt.2639. Epub 2022 Aug 8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35938294/
2022

Impedance-Based Phenotypic Readout of Transporter Function: A Case for Glutamate Transporters

 Hubert J Sijben, Laura Dall' Acqua, Rongfang Liu, Abigail Jarret, Eirini Christodoulaki, Svenja Onstein, Gernot Wolf, Simone J Verburgt, Sylvia E Le Dévédec, Tabea Wiedmer, Giulio Superti-Furga, Adriaan P IJzerman, Laura H Heitman.
Front Pharmacol. 2022 May 23;13:872335. doi: 10.3389/fphar.2022.872335. eCollection 2022.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35677430/
2022

Targeting solute carriers to modulate receptor-ligand interactions

 Hubert J Sijben, Giulio Superti-Furga, Adriaan P IJzerman, Laura H Heitman.
Trends Pharmacol Sci. 2022 May;43(5):358-361. doi: 10.1016/j.tips.2022.02.004. Epub 2022 Feb 26.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35232590/
Year
Paper
2021
Tabata K, Prasad V, Paul D, Lee JY, Pham MT, Twu WI, Neufeldt CJ, Cortese M, Cerikan B, Stahl Y, Joecks S, Tran CS, Lüchtenborg C, V'kovski P, Hörmann K, Müller AC, Zitzmann C, Haselmann U, Beneke J, Kaderali L, Erfle H, Thiel V, Lohmann V, Superti-Furga G, Brügger B, Bartenschlager R. Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation. Nat Commun. 2021 Dec 14;12(1):7276. doi: 10.1038/s41467-021-27511-1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34907161/
2021
Pennemann FL, Mussabekova A, Urban C, Stukalov A, Andersen LL, Grass V, Lavacca TM, Holze C, Oubraham L, Benamrouche Y, Girardi E, Boulos RE, Hartmann R, Superti-Furga G, Habjan M, Imler JL, Meignin C, Pichlmair A. Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators. Nat Commun. 2021 Dec 1;12(1):7009. doi: 10.1038/s41467-021-27192-w.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34853303/
2021
Dvorak V, Wiedmer T, Ingles-Prieto A, Altermatt P, Batoulis H, Bärenz F, Bender E, Digles D, Dürrenberger F, Heitman LH, IJzerman AP, Kell DB, Kickinger S, Körzö D, Leippe P, Licher T, Manolova V, Rizzetto R, Sassone F, Scarabottolo L, Schlessinger A, Schneider V, Sijben HJ, Steck AL, Sundström H, Tremolada S, Wilhelm M, Wright Muelas M, Zindel D, Steppan CM, Superti-Furga G. An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters. Front Pharmacol. 2021 Aug 10;12:722889. doi: 10.3389/fphar.2021.722889. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34447313/
2021
Pemovska T, Bigenzahn JW, Srndic I, Lercher A, Bergthaler A, César-Razquin A, Kartnig F, Kornauth C, Valent P, Staber PB, Superti-Furga G. Metabolic drug survey highlights cancer cell dependencies and vulnerabilities. Nat Commun. 2021 Dec 14;12(1):7190. doi: 10.1038/s41467-021-27329-x.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34907165/
2021
Li KC, Girardi E, Kartnig F, Grosche S, Pemovska T, Bigenzahn JW, Goldmann U, Sedlyarov V, Bensimon A, Schick S, Lin JG, Gürtl B, Reil D, Klavins K, Kubicek S, Sdelci S, Superti-Furga G. Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states. Nat Metab. 2021 May;3(5):651-664. doi: 10.1038/s42255-021-00386-8. Epub 2021 May 10.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33972798/
2021
Li KC, Girardi E, Kartnig F, Grosche S, Pemovska T, Bigenzahn JW, Goldmann U, Sedlyarov V, Bensimon A, Schick S, Lin JG, Gürtl B, Reil D, Klavins K, Kubicek S, Sdelci S, Superti-Furga G. Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states. Nat Metab. 2021 May;3(5):651-664. doi: 10.1038/s42255-021-00386-8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33972798/ _blank
2021
Kornauth C, Pemovska T, Vladimer GI, Bayer G, Bergmann M, Eder S, Eichner R, Erl M, Esterbauer H, Exner R, Felsleitner-Hauer V, Forte M, Gaiger A, Geissler K, Greinix HT, Gstöttner W, Hacker M, Hartmann BL, Hauswirth AW, Heinemann T, Heintel D, Hoda MA, Hopfinger G, Jaeger U, Kazianka L, Kenner L, Kiesewetter B, Krall N, Krajnik G, Kubicek S, Le T, Lubowitzki S, Mayerhoefer ME, Menschel E, Merkel O, Miura K, Müllauer L, Neumeister P, Noesslinger T, Ocko K, Öhler L, Panny M, Pichler A, Porpaczy E, Prager GW, Raderer M, Ristl R, Ruckser R, Salamon J, Schiefer AI, Schmolke AS, Schwarzinger I, Selzer E, Sillaber C, Skrabs C, Sperr WR, Srndic I, Thalhammer R, Valent P, van der Kouwe E, Vanura K, Vogt S, Waldstein C, Wolf D, Zielinski CC, Zojer N, Simonitsch-Klupp I, Superti-Furga G, Snijder B, Staber PB. Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematological Cancers and Identifies Exceptional Responders. Cancer Discov. 2021 Oct 11:candisc.0538.2021. doi: 10.1158/2159-8290.CD-21-0538.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34635570/ _blank
2021
Pizzagalli MD, Bensimon A, Superti-Furga G. A guide to plasma membrane solute carrier proteins. FEBS J. 2021 May;288(9):2784-2835. doi: 10.1111/febs.15531. Epub 2020 Sep 18.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32810346/
2021
Valent P, Orfao A, Kubicek S, Staber P, Haferlach T, Deininger M, Kollmann K, Lion T, Virgolini I, Winter G, Hantschel O, Kenner L, Zuber J, Grebien F, Moriggl R, Hoermann G, Hermine O, Andreeff M, Bock C, Mughal T, Constantinescu SN, Kralovics R, Sexl V, Skoda R, Superti-Furga G, Jäger U. Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions. Hemasphere. 2021 Feb 17;5(3):e536. doi: 10.1097/HS9.0000000000000536. eCollection 2021 Mar.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33623882/
2021
Casiraghi A, Bensimon A, Superti-Furga G. Recent developments in ligands and chemical probes targeting solute carrier transporters. Curr Opin Chem Biol. 2021 Mar 6;62:53-63. doi: 10.1016/j.cbpa.2021.01.012. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33689964/
2020
Krall N, Superti-Furga G, Vladimer GI. Patient-derived model systems and the development of next-generation anticancer therapeutics. Curr Opin Chem Biol. 2020 Jun;56:72-78. doi: 10.1016/j.cbpa.2020.01.002. Epub 2020 Feb 18.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32086157/
2020
Bensimon A, Pizzagalli MD, Kartnig F, Dvorak V, Essletzbichler P, Winter GE, Superti-Furga G. Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis. Cell Chem Biol. 2020 Jun 18;27(6):728-739.e9. doi: 10.1016/j.chembiol.2020.04.003. Epub 2020 May 7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32386596/
2020
Girardi E, Superti-Furga G. Caught in the genetic network: a novel regulator of lipid metabolism. Nat Metab. 2020 Jun;2(6):483-484. doi: 10.1038/s42255-020-0218-5.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32694730/
2020
Meixner E, Goldmann U, Sedlyarov V, Scorzoni S, Rebsamen M, Girardi E, Superti-Furga G. A substrate-based ontology for human solute carriers. Mol Syst Biol. 2020 Jul;16(7):e9652. doi: 10.15252/msb.20209652.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32697042/
2020
Wuerth JD, Habjan M, Kainulainen M, Berisha B, Bertheloot D, Superti-Furga G, Pichlmair A, Weber F. eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition. mBio. 2020 Jul 14;11(4):e00976-20. doi: 10.1128/mBio.00976-20.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32665273/
2020
Pizzagalli MD, Bensimon A, Superti-Furga G. A guide to plasma membrane solute carrier proteins. FEBS J. 2021 May;288(9):2784-2835. doi: 10.1111/febs.15531. Epub 2020 Sep 18.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32810346/
2020
Popa A, Genger JW, Nicholson MD, Penz T, Schmid D, Aberle SW, Agerer B, Lercher A, Endler L, Colaço H, Smyth M, Schuster M, Grau ML, Martínez-Jiménez F, Pich O, Borena W, Pawelka E, Keszei Z, Senekowitsch M, Laine J, Aberle JH, Redlberger-Fritz M, Karolyi M, Zoufaly A, Maritschnik S, Borkovec M, Hufnagl P, Nairz M, Weiss G, Wolfinger MT, von Laer D, Superti-Furga G, Lopez-Bigas N, Puchhammer-Stöckl E, Allerberger F, Michor F, Bock C, Bergthaler A. Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2. Sci Transl Med. 2020 Dec 9;12(573):eabe2555. doi: 10.1126/scitranslmed.abe2555. Epub 2020 Nov 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33229462/
2020
Girardi E, Agrimi G, Goldmann U, Fiume G, Lindinger S, Sedlyarov V, Srndic I, Gürtl B, Agerer B, Kartnig F, Scarcia P, Di Noia MA, Liñeiro E, Rebsamen M, Wiedmer T, Bergthaler A, Palmieri L, Superti-Furga G. Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import. Nat Commun. 2020 Dec 1;11(1):6145. doi: 10.1038/s41467-020-19871-x.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33262325/
2020
Heinz LX, Lee J, Kapoor U, Kartnig F, Sedlyarov V, Papakostas K, César- Razquin A, Essletzbichler P, Goldmann U, Stefanovic A, Bigenzahn JW, Scorzoni S, Pizzagalli MD, Bensimon A, Müller AC, King FJ, Li J, Girardi E, Mbow ML, Whitehurst CE, Rebsamen M, Superti-Furga G. TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9. Nature. 2020 May;581(7808):316-322. doi: 10.1038/s41586-020-2282-0. Epub 2020 May 13.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32433612
2020
Girardi E, César-Razquin A, Lindinger S, Papakostas K, Konecka J, Hemmerich J, Kickinger S, Kartnig F, Gürtl B, Klavins K, Sedlyarov V, Ingles-Prieto A, Fiume G, Koren A, Lardeau CH, Kumaran Kandasamy R, Kubicek S, Ecker GF, Superti-Furga G. A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs. Nat Chem Biol. 2020 Apr;16(4):469-478. doi: 10.1038/s41589-020-0483-3. Epub 2020 Mar 9.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32152546
2019
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM. Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions. Haematologica. 2019 Oct;104(10):1935-1949. doi: 10.3324/haematol.2019.222059.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31048353/
2019
Steinparzer I, Sedlyarov V, Rubin JD, Eislmayr K, Galbraith MD, Levandowski CB, Vcelkova T, Sneezum L, Wascher F, Amman F, Kleinova R, Bender H, Andrysik Z, Espinosa JM, Superti-Furga G, Dowell RD, Taatjes DJ, Kovarik P. Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. Mol Cell. 2019 Nov 7;76(3):485-499.e8. doi: 10.1016/j.molcel.2019.07.034.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31495563/
2019
Ferreira da Silva J, Salic S, Wiedner M, Datlinger P, Essletzbichler P, Hanzl A, Superti-Furga G, Bock C, Winter G, Loizou JI. Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells. Sci Rep. 2019 Oct 31;9(1):15751. doi: 10.1038/s41598-019-52078-9.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31673055/
2019
Doukas A, Karena E, Botou M, Papakostas K, Papadaki A, Tziouvara O, Xingi E, Frillingos S, Boleti H. Heterologous expression of the mammalian sodium-nucleobase transporter rSNBT1 in Leishmania tarentolae. Biochim Biophys Acta Biomembr. 2019 Sep 1;1861(9):1546-1557. doi: 10.1016/j.bbamem.2019.07.001.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31283918/
2019
Conde CD, Petronczki ÖY, Baris S, Willmann KL, Girardi E, Salzer E, Weitzer S, Ardy RC, Krolo A, Ijspeert H, Kiykim A, Karakoc-Aydiner E, Förster-Waldl E, Kager L, Pickl WF, Superti-Furga G, Martínez J, Loizou JI, Ozen A, van der Burg M, Boztug K. Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress. J Clin Invest. 2019 Oct 1;129(10):4194-4206. doi: 10.1172/JCI128903.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31449058/
2019
Buettner R, Nguyen LXT, Kumar B, Morales C, Liu C, Chen LS, Pemovska T, Synold TW, Palmer J, Thompson R, Li L, Hoang DH, Zhang B, Ghoda L, Kowolik C, Kontro M, Leitch C, Wennerberg K, Yu X, Chen CC, Horne D, Gandhi V, Pullarkat V, Marcucci G, Rosen S1. 8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia. J Cell Physiol. 2019 Feb 15. doi: 10.1002/jcp.28294.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30770553/
2019
Bösl K, Ianevski A, Than TT, Andersen PI, Kuivanen S, Teppor M, Zusinaite E, Dumpis U, Vitkauskiene A, Cox RJ, Kallio-Kokko H, Bergqvist A, Tenson T, Merits A, Oksenych V, Bjørås M, Anthonsen MW, Shum D, Kaarbø M, Vapalahti O, Windisch MP, Superti-Furga G, Snijder B, Kainov D, Kandasamy RK. Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis. Front Immunol. 2019 Oct 4;10:2186. doi: 10.3389/fimmu.2019.02186.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31636628/
2019
Skucha A, Ebner J, Grebien F. Roles of SETD2 in Leukemia-Transcription, DNA-Damage, and Beyond. Int J Mol Sci. 2019 Feb 27;20(5). pii: E1029. doi:10.3390/ijms20051029. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30818762
2019
Schmidl C, Vladimer GI, Rendeiro AF, Schnabl S, Krausgruber T, Taubert C,Krall N, Pemovska T, Araghi M, Snijder B, Hubmann R, Ringler A, Runggatscher K,Demirtas D, de la Fuente OL, Hilgarth M, Skrabs C, Porpaczy E, Gruber M, HoermannG, Kubicek S, Staber PB, Shehata M, Superti-Furga G, Jäger U, Bock C. Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL. Nat Chem Biol. 2019 Mar;15(3):232-240. doi: 10.1038/s41589-018-0205-2. Epub 2019 Jan 28.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30692684
2019
Scalise M, Galluccio M, Pochini L, Cosco J, Trotta M, Rebsamen M,Superti-Furga G, Indiveri C. Insights into the transport side of the human SLC38A9 transceptor. Biochim Biophys Acta Biomembr. 2019 Jul 8;1861(9):1558-1567.doi: 10.1016/j.bbamem.2019.07.006. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31295473
2019
Moskovskich A, Goldmann U, Kartnig F, Lindinger S, Konecka J, Fiume G,Girardi E, Superti-Furga G. The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection. Sci Rep. 2019 Jul 18;9(1):10471.doi: 10.1038/s41598-019-46952-9.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31320712
2019
Mian AA, Baumann I, Liebermann M, Grebien F, Superti-Furga G, Ruthardt M,Ottmann OG, Hantschel O. The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis. Leukemia. 2019 Apr 8. doi:10.1038/s41375-019-0468-y. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30962580
2019
Fauster A, Rebsamen M, Willmann KL, César-Razquin A, Girardi E, Bigenzahn JW,Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hörmann K, Heinz LX, Boztug K,Superti-Furga G. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019Jun;26(6):1138-1155. doi: 10.1038/s41418-018-0192-6. Epub 2018 Sep 20.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30237509
2019
Brandstetter B, Dalwigk K, Platzer A, Niederreiter B, Kartnig F, Fischer A,Vladimer GI, Byrne RA, Sevelda F, Holinka J, Pap T, Steiner G, Superti-Furga G,Smolen JS, Kiener HP, Karonitsch T. FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synoviocytes. Lab Invest. 2019 May;99(5):648-658. doi: 10.1038/s41374-018-0184-7. Epub 2019 Jan 24.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30679758
2019
Bonelli M, Dalwigk K, Platzer A, Olmos Calvo I, Hayer S, Niederreiter B,Holinka J, Sevelda F, Pap T, Steiner G, Superti-Furga G, Smolen JS, Kiener HP,Karonitsch T. IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes : JAKinibs suppress the interferon response in RA-FLSs. Exp Mol Med. 2019 Jul 8;51(7):75. doi:10.1038/s12276-019-0267-6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31285419
2019
Andergassen D, Muckenhuber M, Bammer PC, Kulinski TM, Theussl HC, Shimizu T,Penninger JM, Pauler FM, Hudson QJ. The Airn lncRNA does not require any DNAelements within its locus to silence distant imprinted genes. PLoS Genet. 2019Jul 22;15(7):e1008268. doi: 10.1371/journal.pgen.1008268. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31329595
2018
Wuerth JD, Habjan M, Wulle J, Superti-Furga G, Pichlmair A, Weber F. NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3. J Virol. 2018 Nov 12;92(23). pii: e01202-18. doi: 10.1128/JVI.01202-18. Print 2018 Dec 1.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30232186
2018
Tsafou K, Katschnig AM, Radic-Sarikas B, Mutz CN, Iljin K, Schwentner R, Kauer MO, Mühlbacher K, Aryee DNT, Westergaard D, Haapa-Paananen S, Fey V, Superti-Furga G, Toretsky J, Brunak S, Kovar H. Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers. Oncotarget. 2018 Jul 24;9(57):31018-31031. doi: 10.18632/oncotarget.25760. eCollection 2018 Jul 24.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30123424
2018
Skucha A, Ebner J, Grebien F. SETD2 in MLL-rearranged leukemia - a complex case. Mol Cell Oncol. 2018 Aug 13;5(4):e1503492. doi: 10.1080/23723556.2018.1503492. eCollection 2018.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29932108
2018
Pemovska T, Bigenzahn JW, Superti-Furga G. Recent advances in combinatorial drug screening and synergy scoring. Curr Opin Pharmacol. 2018 Oct;42:102-110. doi: 10.1016/j.coph.2018.07.008. Epub 2018 Sep 5. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30193150
2018
Fauster A, Rebsamen M, Willmann KL, César-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hörmann K, Heinz LX, Boztug K, Superti-Furga G. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2018 Sep 20. doi: 10.1038/s41418-018-0192-6. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30237509
2018
César-Razquin A, Girardi E, Yang M, Brehme M, Saez-Rodriguez J, Superti-Furga G. In silico Prioritization of Transporter-Drug Relationships From Drug Sensitivity Screens. Front Pharmacol. 2018 Sep 7;9:1011. doi: 10.3389/fphar.2018.01011. eCollection 2018.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30245630
2018
Bigenzahn JW, Collu GM, Kartnig F, Pieraks M, Vladimer GI, Heinz LX, Sedlyarov V, Schischlik F, Fauster A, Rebsamen M, Parapatics K, Blomen VA, Müller AC, Winter GE, Kralovics R, Brummelkamp TR, Mlodzik M, Superti-Furga G. LZTR1 is a regulator of RAS ubiquitination and signaling. Science. 2018 Nov 15. pii: eaap8210. doi: 10.1126/science.aap8210. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30442766
2018
Lee SE, Song J, Bösl K, Müller AC, Vitko D, Bennett KL, Superti-Furga G, Pandey A, Kandasamy RK, Kim MS. Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines. Proteomics. 2018 Apr;18(8):e1700386. doi: 10.1002/pmic.201700386.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29474001
2018
Karonitsch T, Kandasamy RK, Kartnig F, Herdy B, Dalwigk K, Niederreiter B, Holinka J, Sevelda F, Windhager R, Bilban M, Weichhart T, Säemann M, Pap T, Steiner G, Smolen JS, Kiener HP, Superti-Furga G. mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation. Cell Rep. 2018 May 15;23(7):2157-2167. doi: 10.1016/j.celrep.2018.04.044.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29768212
2018
Skucha A, Ebner J, Schmöllerl J, Roth M, Eder T, César-Razquin A, Stukalov A, Vittori S, Muhar M, Lu B, Aichinger M, Jude J, Müller AC, Győrffy B, Vakoc CR, Valent P, Bennett KL, Zuber J, Superti-Furga G, Grebien F. MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity. Nat Commun. 2018 May 18;9(1):1983. doi: 10.1038/s41467-018-04329-y.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29777171
2018
Sedlyarov V, Eichner R, Girardi E, Essletzbichler P, Goldmann U, Nunes-Hasler P, Srndic I, Moskovskich A, Heinz LX, Kartnig F, Bigenzahn JW, Rebsamen M, Kovarik P, Demaurex N, Superti-Furga G. The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification. Cell Host Microbe. 2018 Jun 13;23(6):766-774.e5. doi: 10.1016/j.chom.2018.04.013.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29779931
2018
Hashimoto M, Girardi E, Eichner R, Superti-Furga G. Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay. ACS Chem Biol. 2018 Jun 6. doi: 10.1021/acschembio.8b00270. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29851333
2017
Radic-Sarikas B, Tsafou KP, Emdal KB, Papamarkou T, Huber KV, Mutz C, Toretsky JA, Bennett KL, Olsen JV, Brunak S, Kovar H, Superti-Furga G. Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities. Mol Cancer Ther. 2017 Jan;16(1):88-101. doi: 10.1158/1535-7163.MCT-16-0235. Epub 2016 Nov 15.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28062706
2017
Korcsmaros T, Schneider MV, Superti-Furga G. Next generation of network medicine: interdisciplinary signaling approaches. Integr Biol (Camb). 2017 Feb 20;9(2):97-108. doi: 10.1039/c6ib00215c. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28106223
2017
Conte C, Roscini L, Sardella R, Mariucci G, Scorzoni S, Beccari T, Corte L. Toll Like Receptor 4 Affects the Cerebral Biochemical Changes Induced by MPTP Treatment. Neurochem Res. 2017 Feb;42(2):493-500. doi: 10.1007/s11064-016-2095-6. Epub 2017 Jan 21.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28108849
2017
Pietarinen PO, Eide CA, Ayuda-Durán P, Potdar S, Kuusanmäki H, Andersson EI, Mpindi JP, Pemovska T, Kontro M, Heckman CA, Kallioniemi O, Wennerberg K, Hjorth-Hansen H, Druker BJ, Enserink JM, Tyner JW, Mustjoki S, Porkka K. Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors. Oncotarget. 2017 Apr 4;8(14):22606-22615. doi: 10.18632/oncotarget.15146.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28186983
2017
Valent P, Herndlhofer S, Schneeweiß M, Boidol B, Ringler A, Kubicek S, Gleixner KV, Hoermann G, Hadzijusufovic E, Müllauer L, Sperr WR, Superti-Furga G, Mannhalter C. TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML. Oncotarget. 2017 Apr 4;8(14):23061-23072. doi: 10.18632/oncotarget.15481.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28416739
2017
Vladimer GI, Snijder B, Krall N, Bigenzahn JW, Huber KVM, Lardeau CH, Sanjiv K, Ringler A, Berglund UW, Sabler M, de la Fuente OL, Knöbl P, Kubicek S, Helleday T, Jäger U, Superti-Furga G. Global survey of the immunomodulatory potential of common drugs. Nat Chem Biol. 2017 Jun;13(6):681-690. doi: 10.1038/nchembio.2360. Epub 2017 Apr 24.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28437395
2017
Radic-Sarikas B, Halasz M, Huber KVM, Winter GE, Tsafou KP, Papamarkou T, Brunak S, Kolch W, Superti-Furga G. Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter. Sci Rep. 2017 Jun 8;7(1):3091. doi: 10.1038/s41598-017-03129-6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28596528
2017
Sedlyarova N, Rescheneder P, Magán A, Popitsch N, Rziha N, Bilusic I, Epshtein V, Zimmermann B, Lybecker M, Sedlyarov V, Schroeder R, Nudler E. Natural RNA Polymerase Aptamers Regulate Transcription in E. coli. Mol Cell. 2017 Jul 6;67(1):30-43.e6. doi: 10.1016/j.molcel.2017.05.025. Epub 2017 Jun 22.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28648779
2017
Hadzijusufovic E, Albrecht-Schgoer K, Huber K, Hoermann G, Grebien F, Eisenwort G, Schgoer W, Herndlhofer S, Kaun C, Theurl M, Sperr WR, Rix U, Sadovnik I, Jilma B, Schernthaner GH, Wojta J, Wolf D, Superti-Furga G, Kirchmair R, Valent P. Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site. Leukemia. 2017 Nov;31(11):2388-2397. doi: 10.1038/leu.2017.245. Epub 2017 Jul 31.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28757617
2017
Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, Fürnrohr BG, Lechner S, Dunzendorfer-Matt T, Scheffzek K, Bennett KL, Superti-Furga G, Lindner HH, Stasyk T, Huber LA. LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning. J Cell Biol. 2017 Oct 9. pii: jcb.201703061. doi: 10.1083/jcb.201703061. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28993467
2016
Li J, Casteels T, Frogne T, Ingvorsen C, Honoré C, Courtney M, Huber KVM, Schmitner N, Kimmel RA, Romanov RA, Sturtzel C, Lardeau CH, Klughammer J, Farlik M, Sdelci S, Vieira A, Avolio F, Briand F, Baburin I, Májek P, Pauler FM, Penz T, Stukalov A, Gridling M, Parapatics K, Barbieux C, Berishvili E, Spittler A, Colinge J, Bennett KL, Hering S, Sulpice T, Bock C, Distel M, Harkany T, Meyer D, Superti-Furga G, Collombat P, Hecksher-Sørensen J, and Kubicek S. Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity, Cell 2017 Jan 12 (epub ahead of print 2016 Dec 1);168(1), 86-100. doi:10.1016/j.cell.2016.11.010.Abstract: http://www.cell.com/cell/abstract/S0092-8674(16)31531-8
2016
Peter B, Winter GE, Blatt K, Bennett KL, Stefanzl G, Rix U, Eisenwort G, Hadzijusufovic E, Gridling M, Dutreix C, Hoermann G, Schwaab J, Radia D, Roesel J, Manley PW, Reiter A, Superti-Furga G, Valent P. Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth. Leukemia. 2016 Feb;30(2):464-72. doi: 10.1038/leu.2015.242.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/26349526
2016
Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, Moran MF, Grynpas MD, Wrana JL, Superti-Furga G, Koleske AJ, Pendergast AM, Rottapel R. Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. J Clin Invest. 2016 Dec 1;126(12):4482-4496. doi: 10.1172/JCI87802.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27797343
2016
Martins R, Maier J, Gorki AD, Huber KV, Sharif O, Starkl P, Saluzzo S, Quattrone F, Gawish R, Lakovits K, Aichinger MC, Radic-Sarikas B, Lardeau CH, Hladik A, Korosec A, Brown M, Vaahtomeri K, Duggan M, Kerjaschki D, Esterbauer H, Colinge J, Eisenbarth SC, Decker T, Bennett KL, Kubicek S, Sixt M, Superti-Furga G, Knapp S. Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions. Nat Immunol. 2016 Oct 31. doi: 10.1038/ni.3590.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27798618
2016
Gorelik A, Heinz LX, Illes K, Superti-Furga G, Nagar B. Crystal Structure of the Acid Sphingomyelinase-Like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity. J Biol Chem. 2016 Sep 28. pii: jbc.M116.755801.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27687724
2016
Byrgazov K, Kastner R, Gorna M, Hoermann G, Koenig M, Lucini CB, Ulreich R, Benesch M, Strenger V, Lackner H, Schwinger W, Sovinz P, Haas OA, van den Heuvel-Eibrink M, Niemeyer CM, Hantschel O, Valent P, Superti-Furga G, Urban C, Dworzak MN, Lion T. NDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors. Leukemia. 2016 Oct 7. doi: 10.1038/leu.2016.250.
Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220134/
2016
van Karnebeek CD, Bonafé L, Wen XY, Tarailo-Graovac M, Balzano S, Royer-Bertrand B, Ashikov A, Garavelli L, Mammi I, Turolla L, Breen C, Donnai D, Cormier V, Heron D, Nishimura G, Uchikawa S, Campos-Xavier B, Rossi A, Hennet T, Brand-Arzamendi K, Rozmus J, Harshman K, Stevenson BJ, Girardi E, Superti-Furga G, Dewan T, Collingridge A, Halparin J, Ross CJ, Van Allen MI, Rossi A, Engelke UF, Kluijtmans LA, van der Heeft E, Renkema H, de Brouwer A, Huijben K, Zijlstra F, Heisse T, Boltje T, Wasserman WW, Rivolta C, Unger S, Lefeber DJ, Wevers RA, Superti-Furga A. NANS-mediated synthesis of sialic acid is required for brain and skeletal development. Nat Genet. 2016 May 23. doi: 10.1038/ng.3578.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27213289
2016
Tortola L, Nitsch R, Bertrand MJ, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 2016 May 17;15(7):1481-92. doi: 10.1016/j.celrep.2016.04.032. Epub 2016 May 5.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27160902
2016
Sdelci S, Lardeau CH, Tallant C, Klepsch F, Klaiber B, Bennett J, Rathert P, Schuster M, Penz T, Fedorov O, Superti-Furga G, Bock C, Zuber J, Huber KV, Knapp S, Müller S, Kubicek S. Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk. Nat Chem Biol. 2016 May 9. doi: 10.1038/nchembio.2080.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27159579
2016
Pathria G, Garg B, Borgdorff V, Garg K, Wagner C, Superti-Furga G, Wagner SN. Overcoming MITF-conferred drug resistance through dual AURKA/MAPK targeting in human melanoma cells. Cell Death Dis. 2016 Mar 10;7:e2135. doi: 10.1038/cddis.2015.369.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26962685
2016
Müller AC, Giambruno R, Weißer J, Májek P, Hofer A, Bigenzahn JW, Superti-Furga G, Jessen HJ, Bennett KL. Identifying Kinase Substrates via a Heavy ATP Kinase Assay and Quantitative Mass Spectrometry. Sci Rep. 2016 Jun 27;6:28107. doi: 10.1038/srep28107.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27346722
2016
Köberlin MS, Heinz LX, Superti-Furga G. Functional crosstalk between membrane lipids and TLR biology. Curr Opin Cell Biol. 2016 Feb 16;39:28-36. doi: 10.1016/j.ceb.2016.01.010.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26895312
2016
Gorelik A, Illes K, Superti-Furga G, Nagar B. Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-Like Phosphodiesterase SMPDL3A. J Biol Chem. 2016 Jan 20. pii: jbc.M115.711085.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26792860
2016
Gorelik A, Illes K, Heinz LX, Superti-Furga G, Nagar B. Crystal structure of mammalian acid sphingomyelinase. Nat Commun. 2016 Jul 20;7:12196. doi: 10.1038/ncomms12196.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27435900
2015
Royer-Bertrand B, Castillo-Taucher S, Moreno-Salinas R, Cho TJ, Chae JH, Choi M, Kim OH, Dikoglu E, Campos-Xavier B, Girardi E, Superti-Furga G, Bonafé L, Rivolta C, Unger S, Superti-Furga A. Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia. Sci Rep. 2015 Nov 24;5:17154. doi: 10.1038/srep17154.
Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657157/
2015
Rebsamen M, Superti-Furga G. SLC38A9: a lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1. Autophagy. 2015 Oct 2:0.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26431368
2015
Peter B, Winter GE, Blatt K, Bennett KL, Stefanzl G, Rix U, Eisenwort G, Hadzijusufovic E, Gridling M, Dutreix C, Hoermann G, Schwaab J, Radia D, Roesel J, Manley PW, Reiter A, Superti-Furga G, Valent P. Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth. Leukemia. 2015 Sep 9. doi: 10.1038/leu.2015.242.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26349526
2015
Licciardello MP, Müllner MK, Dürnberger G, Kerzendorfer C, Boidol B, Trefzer C, Sdelci S, Berg T, Penz T, Schuster M, Bock C, Kralovics R, Superti-Furga G, Colinge J, Nijman SM, Kubicek S. NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation. Oncogene. 2015 Jul;34(29):3780-90. doi: 10.1038/onc.2014.319. Epub 2014 Sep 29.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25263445
2015
Huber KV, Superti-Furga G. Profiling of Small Molecules by Chemical Proteomics. Methods Mol Biol. Dec 24, 2015;1394:211-8. doi: 10.1007/978-1-4939-3341-9_15.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26700051
2015
Huber KV, Olek KM, Müller AC, Tan CS, Bennett KL, Colinge J, Superti-Furga G. Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling. Nat Methods. 2015 Nov;12(11):1055-7. doi: 10.1038/nmeth.3590. Epub 2015 Sep 21.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26389571
2015
Hörmann K, Stukalov A, Müller AC, Heinz LX, Superti-Furga G, Colinge J, Bennett KL. A surface biotinylation strategy for reproducible plasma membrane protein purification and tracking of genetic and drug-induced alterations. J Proteome Res. 2015 Dec 24.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26699813
2015
Harutyunyan AS, Giambruno R, Krendl C, Stukalov A, Klampfl T, Berg T, Chen D, Milosevic Feenstra JD, Jäger R, Gisslinger B, Gisslinger H, Rumi E, Passamonti F, Pietra D, Müller AC, Parapatics K, Breitwieser FP, Herrmann R, Colinge J, Bennett KL, Superti-Furga G, Cazzola M, Hammond E, Kralovics R. Germline RBBP6 mutations in familial myeloproliferative neoplasms. Blood. 2015 Nov 16. pii: blood-2015-09-668673.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26574608
2015
César-Razquin A, Snijder B, Frappier-Brinton T, Isserlin R, Gyimesi G, Bai X, Reithmeier RA, Hepworth D, Hediger MA, Edwards AM, Superti-Furga G. A Call for Systematic Research on Solute Carriers. Cell. 2015 Jul 30;162(3):478-87. doi: 10.1016/j.cell.2015.07.022. Review.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26232220
2015
Blüml S, Sahin E, Saferding V, Goncalves-Alves E, Hainzl E, Niederreiter B, Hladik A, Lohmeyer T, Brunner JS, Bonelli M, Koenders MI, van den Berg WB, Superti-Furga G, Smolen JS, Schabbauer G, Redlich K. Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis. Arthritis Res Ther. 2015 Aug 26;17:230. doi: 10.1186/s13075-015-0742-y.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26307404
2015
Blomen VA, Májek P, Jae LT, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J, Superti-Furga G, Brummelkamp TR. Gene essentiality and synthetic lethality in haploid human cells. Science. 2015 Nov 27;350(6264):1092-6. doi: 10.1126/science.aac7557. Epub 2015 Oct 15.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26472760
2015
Bigenzahn JW, Fauster A, Rebsamen M, Kandasamy RK, Scorzoni S, Vladimer GI, Mueller AC, Gstaiger M, Zuber J, Bennett KL, Superti-Furga G. An inducible retroviral expression system for tandem affinity purification mass-spectrometry-based proteomics identifies MLKL as an HSP90 client. Mol Cell Proteomics. 2015 Dec 29. pii: mcp.O115.055350.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26714523
2015
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ. The promise and peril of chemical probes. Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867. No abstract available. Erratum in: Nat Chem Biol. 2015 Aug;11(8):541. Roth, Brian [Corrected to Roth, Bryan] and Frederiksen, Mathias [Added].
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26248267
2015
Sana TG, Baumann C, Merdes A, Soscia C, Rattei T, Hachani A, Jones C, Bennett KL, Filloux A, Superti-Furga G, Voulhoux R, Bleves S. Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule Network. MBio. 2015 Jun 2;6(3). pii: e00712-15. doi: 10.1128/mBio.00712-15.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26037124
2015
Rebsamen M, Pochini L, Stasyk T, de Araújo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature. 2015 Jan 7. doi: 10.1038/nature14107.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25561175
2015
Muellner MK, Mair B, Ibrahim Y, Kerzendorfer C, Lechtermann H, Trefzer C, Klepsch F, Müller AC, Leitner E, Macho-Maschler S, Superti-Furga G, Bennett KL, Baselga J, Rix U, Kubicek S, Colinge J, Serra V, Nijman SM. Targeting a cell state common to triple-negative breast cancers. Mol Syst Biol. 2015 Feb 19;11(1):789. doi: 10.15252/msb.20145664.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25699542
2015
Lorenz S, Deng P, Hantschel O, Superti-Furga G, Kuriyan J. Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity. Biochem J. 2015 Jun 1;468(2):283-91. doi: 10.1042/BJ20141492.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/?term=lorenz+s+superti-furga
2015
Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, Müller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC. Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3056-61. doi: 10.1073/pnas.1501554112. Epub 2015 Feb 23.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25713392
2015
Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, Snijder B, Superti-Furga G, Gonen H, Sommer T, Ziv T, Admon A, Naroditsky I, Jbara M, Brik A, Pikarsky E, Kwon YT, Doweck I, Ciechanover A. KPC1-mediated ubiquitination and proteasomal processing of NF-_B1 p105 to p50 restricts tumor growth. Cell. 2015 Apr 9;161(2):333-47. doi: 10.1016/j.cell.2015.03.001.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25860612
2015
Köberlin MS, Snijder B, Heinz LX, Baumann CL, Fauster A, Vladimer GI, Gavin AC, Superti-Furga G. A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses. Cell. 2015 Jul 2;162(1):170-83. doi: 10.1016/j.cell.2015.05.051. Epub 2015 Jun 18.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26095250
2015
Hofer A, Cremosnik GS, Müller AC, Giambruno R, Trefzer C, Superti-Furga G, Bennett KL, Jessen HJ. A Modular Synthesis of Modified Phosphoanhydrides. Chemistry. 2015 Jun 1. doi: 10.1002/chem.201500838.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26033174
2015
Herdy B, Karonitsch T, Vladimer GI, Tan CS, Stukalov A, Trefzer C, Bigenzahn JW, Theil T, Holinka J, Kiener HP, Colinge J, Bennett KL, Superti-Furga G. The RNA-binding protein HuR/ELAVL1 regulates IFN-_ mRNA abundance and the type I IFN response. Eur J Immunol. 2015 May;45(5):1500-11. doi: 10.1002/eji.201444979. Epub 2015 Mar 12.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25678110
2015
Heinz LX, Baumann CL, Köberlin MS, Snijder B, Gawish R, Shui G, Sharif O, Aspalter IM, Müller AC, Kandasamy RK, Breitwieser FP, Pichlmair A, Bruckner M, Rebsamen M, Blüml S, Karonitsch T, Fauster A, Colinge J, Bennett KL, Knapp S, Wenk MR, Superti-Furga G. The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell Rep. 2015 Jun 30;11(12):1919-28. doi: 10.1016/j.celrep.2015.05.006.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26095358
2015
Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, Dong A, Senisterra G, Stukalov A, Huber KV, Schönegger A, Marcellus R, Bilban M, Bock C, Brown PJ, Zuber J, Bennett KL, Al-Awar R, Delwel R, Nerlov C, Arrowsmith CH, Superti-Furga G. Pharmacological targeting of the Wdr5-MLL interaction in C/EBP_ N-terminal leukemia. Nat Chem Biol. 2015 Jul 13. doi: 10.1038/nchembio.1859.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26167872
2015
Fauster A, Rebsamen M, Huber KV, Bigenzahn JW, Stukalov A, Lardeau CH, Scorzoni S, Bruckner M, Gridling M, Parapatics K, Colinge J, Bennett KL, Kubicek S, Krautwald S, Linkermann A, Superti-Furga G. A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis. Cell Death Dis. 2015 May 21;6:e1767. doi: 10.1038/cddis.2015.130.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25996294
2015
Dixon SJ, Winter GE, Musavi LS, Lee ED, Snijder B, Rebsamen M, Superti-Furga G, Stockwell BR. Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death. ACS Chem Biol. 2015 May 15.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25965523
2015
Dikoglu E, Alfaiz A, Gorna M, Bertola D, Chae JH, Cho TJ, Derbent M, Alanay Y, Guran T, Kim OH, Llerenar JC Jr, Yamamoto G, Superti-Furga G, Reymond A, Xenarios I, Stevenson B, Campos-Xavier B, Bonafé L, Superti-Furga A, Unger S. Mutations in LONP1, a mitochondrial matrix protease, cause CODAS syndrome. Am J Med Genet A. 2015 Mar 21. doi: 10.1002/ajmg.a.37029.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25808063
2014
Winter GE, Radic B, Mayor-Ruiz C, Blomen VA, Trefzer C, Kandasamy RK, Huber KV, Gridling M, Chen D, Klampfl T, Kralovics R, Kubicek S, Fernandez-Capetillo O, Brummelkamp TR, Superti-Furga G. The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity. Nat Chem Biol. 2014 Sep;10(9):768-73. doi: 10.1038/nchembio.1590. Epub 2014 Jul 27.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25064833
2014
Snijder B, Kandasamy RK, Superti-Furga G. Toward effective sharing of high-dimensional immunology data. Nat Biotechnol. 2014 Aug;32(8):755-9. doi: 10.1038/nbt.2974.
Abstract: http://www.nature.com/nbt/journal/v32/n8/full/nbt.2974.html
2014
Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Göktürk C, Sanjiv K, Strömberg K, Pham T, Berglund UW, Colinge J, Bennett KL, Loizou JI, Helleday T, Knapp S, Superti-Furga G. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 2014 Apr 10;508(7495):222-7. doi: 10.1038/nature13194. Epub 2014 Apr 2.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24695225
2014
Gridling M, Ficarro S, Breitwieser FP, Song L, Parapatics K, Colinge J, Haura EB, Marto J, Superti-Furga G, Bennett KL, Rix U. Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics. Mol Cancer Ther. 2014 Sep 4. pii: molcanther.0152.2014. [Epub ahead of print]
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25189542
2014
Giansanti P, Preisinger C, Huber KV, Gridling M, Superti-Furga G, Bennett KL, Heck AJ. Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics. ACS Chem Biol. 2014 Jul 18;9(7):1490-8. doi: 10.1021/cb500116c. Epub 2014 May 14.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24804581
2014
Eberle CA, Zayas M, Stukalov A, Pichlmair A, Alvisi G, Müller AC, Bennett KL, Bartenschlager R, Superti-Furga G. The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production. Virology. 2014 Aug;462-463:34-41. doi: 10.1016/j.virol.2014.05.016. Epub 2014 Jun 14.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25092459
2014
Colinge J, César-Razquin A, Huber K, Breitwieser FP, Májek P, Superti-Furga G. Building and exploring an integrated human kinase network: global organization and medical entry points. J Proteomics. 2014 Jul 31;107:113-27. doi: 10.1016/j.jprot.2014.03.028. Epub 2014 Apr 3.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24704859
2014
Kainulainen M, Habjan M, Hubel P, Busch L, Lau S, Colinge J, Superti-Furga G, Pichlmair A, Weber F. Virulence Factor NSs of Rift Valley Fever Virus Recruits the F-Box Protein FBXO3 To Degrade Subunit p62 of General Transcription Factor TFIIH. J Virol. 2014 Mar;88(6):3464-73. doi: 10.1128/JVI.02914-13. Epub 2014 Jan 8.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24403578
2014
Bonafé L, Liang J, Gorna MW, Zhang Q, Ha-Vinh R, Campos-Xavier AB, Unger S, Beckmann JS, Le Béchec A, Stevenson B, Giedion A, Liu X, Superti-Furga G, Wang W, Spahr A, Superti-Furga A. MMP13 mutations are the cause of recessive metaphyseal dysplasia, Spahr type. Am J Med Genet A. 2014 May;164A(5):1175-9. doi: 10.1002/ajmg.a.36431. Epub 2014 Mar 19.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24648384
2014
Vladimer GI, Górna MW, Superti-Furga G. IFITs: Emerging Roles as Key Anti-Viral Proteins. Front Immunol. 2014 Mar 10;5:94. doi: 10.3389/fimmu.2014.00094. eCollection 2014.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24653722
2014
Liehl P, Zuzarte-Luís V, Chan J, Zillinger T, Baptista F, Carapau D, Konert M, Hanson KK, Carret C, Lassnig C, Müller M, Kalinke U, Saeed M, Chora AF, Golenbock DT, Strobl B, Prudêncio M, Coelho LP, Kappe SH, Superti-Furga G, Pichlmair A, Vigário AM, Rice CM, Fitzgerald KA, Barchet W, Mota MM. Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med. 2014 Jan;20(1):47-53. doi: 10.1038/nm.3424. Epub 2013 Dec 22.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24362933
2014
Karonitsch T, Dalwigk K, Holinka J, Niederreiter B, Steiner CW, Bilban M, Wanivenhaus A, Windhager R, Smolen JS, Kiener HP, Superti-Furga G.1. A dual role of MTOR in the rheumatoid mesenchymal tissue response to inflammation. Ann Rheum Dis. 2014 Mar 1;73 Suppl 1:A3-4. doi: 10.1136/annrheumdis-2013-205124.8.
Abstract: http://ard.bmj.com/content/73/Suppl_1/A3.3
2013
Bürckstümmer T, Banning C, Hainzl P, Schobesberger R, Kerzendorfer C, Pauler FM, Chen D, Them N, Schischlik F, Rebsamen M, Smida M, Fece de la Cruz F, Lapao A, Liszt M, Eizinger B, Guenzl PM, Blomen VA, Konopka T, Gapp B, Parapatics K, Maier B, Stöckl J, Fischl W, Salic S, Taba Casari MR, Knapp S, Bennett KL, Bock C, Colinge J, Kralovics R, Ammerer G, Casari G, Brummelkamp TR, Superti-Furga G, Nijman SM. A reversible gene trap collection empowers haploid genetics in human cells. Nat Methods. 2013 Oct;10(10):965-71.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24161985
2013
Li J, Bennett K, Stukalov A, Fang B, Zhang G, Yoshida T, Okamoto I, Kim JY, Song L, Bai Y, Qian X, Rawal B, Schell M, Grebien F, Winter G, Rix U, Eschrich S, Colinge J, Koomen J, Superti-Furga G, Haura EB. Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Mol Syst Biol. 2013 Nov 5;9:705. doi: 10.1038/msb.2013.61.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24189400
2013
Upadhyay AS, Vonderstein K, Pichlmair A, Stehling O, Bennett KL, Dobler G, Guo JT, Superti-Furga G, Lill R, Overby AK, Weber F. Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity. Cell Microbiol. 2013 Nov 19. doi: 10.1111/cmi.12241. [Epub ahead of print]
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24245804
2013
Fritzsche R, Karra D, Bennett KL, Ang FY, Heraud-Farlow JE, Tolino M, Doyle M, Bauer KE, Thomas S, Planyavsky M, Arn E, Bakosova A, Jungwirth K, Hörmann A, Palfi Z, Sandholzer J, Schwarz M, Macchi P, Colinge J, Superti-Furga G, Kiebler MA. Interactome of two diverse RNA granules links mRNA localization to translational repression in neurons. Cell Rep. 2013 Dec 26;5(6):1749-62. doi: 10.1016/j.celrep.2013.11.023. Epub 2013 Dec 19.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24360960
2013
Liehl P, Zuzarte-Luís V, Chan J, Zillinger T, Baptista F, Carapau D, Konert M, Hanson KK, Carret C, Lassnig C, Müller M, Kalinke U, Saeed M, Chora AF, Golenbock DT, Strobl B, Prudêncio M, Coelho LP, Kappe SH, Superti-Furga G, Pichlmair A, Vigário AM, Rice CM, Fitzgerald KA, Barchet W, Mota MM. Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med. 2013 Dec 22. doi: 10.1038/nm.3424. [Epub ahead of print]
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24362933
2013
Varjosalo M, Sacco R, Stukalov A, van Drogen A, Planyavsky M, Hauri S, Aebersold R, Bennett KL, Colinge J, Gstaiger M, Superti-Furga G. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23455922
2013
Unger S, Górna MW, Le Béchec A, Do Vale-Pereira S, Bedeschi MF, Geiberger S, Grigelioniene G, Horemuzova E, Lalatta F, Lausch E, Magnani C, Nampoothiri S, Nishimura G, Petrella D, Rojas-Ringeling F, Utsunomiya A, Zabel B, Pradervand S, Harshman K, Campos-Xavier B, Bonafé L, Superti-Furga G, Stevenson B, Superti-Furga A. FAM111A Mutations Result in Hypoparathyroidism and Impaired Skeletal Development. Am J Hum Genet. 2013 May 14.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23684011
2013
Rix U, Colinge J, Blatt K, Gridling M, Remsing Rix LL, Parapatics K, Cerny-Reiterer S, Burkard TR, Jäger U, Melo J, Bennett KL, Valent P, Superti-Furga G. A Target-Disease Network Model of Second-Generation BCR-ABL Inhibitor Action in Ph+ ALL. PLoS One. 2013; 8(10): e77155.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24130846
2013
Rebsamen M, Kandasamy RK, Superti-Furga G. Protein interaction networks in innate immunity. Trends Immunol. 2013 Jul 1. S1471-4906(13)00079-3;
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23827258
2013
Mellacheruvu D, Wright Z, Couzens AL, Lambert J-P, St-Denis N, Li T, Mitev YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin Z-Y, Gonzalez Badillo B, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga S, Colinge J, Heck AJR, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras A-C, Nesvizhskii A. The CRAPome: a Contaminant Repository for Affinity Purification Mass Spectrometry Data. Nature Methods May; 24(Suppl): S50–S51.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23921808
2013
Giambruno R, Grebien F, Stukalov A, Knoll C, Planyavsky M, Rudashevskaya EL, Colinge J, Superti-Furga G, Bennett KL. Affinity Purification Strategies for Proteomic Analysis of Transcription Factor Complexes. J Proteome Res. 2013 September 6; 12(9): 4018–4027.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23937658
2013
Borgdorff V, Rix U, Winter GE, Gridling M, Müller AC, Breitwieser FP, Wagner C, Colinge J, Bennett KL, Superti-Furga G, Wagner SN. A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF. Oncogene. 2013 Jun 3.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23728343
2013
Abbas YM, Pichlmair A, Górna MW, Superti-Furga G, Nagar B. Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature. 2013 Feb 7;494(7435):60-4.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23334420
2012
Winter GE, Rix U, Carlson SM, Gleixner KV, Grebien F, Gridling M, Müller AC, Breitwieser FP, Bilban M, Colinge J, Valent P, Bennett KL, White FM, Superti-Furga G. Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML. Nat Chem Biol. 2012 Nov;8(11):905-12.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23023260
2012
Sudol M, Cesareni G, Superti-Furga G, Just W. Special issue – modular protein domains. FEBS Lett. 2012 Aug 14;586(17):2571. Epub 2012 Jun 17.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22713655
2012
Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G. Viral immune modulators perturb the human molecular network by common and unique strategies. Nature. 2012 Jul 26;487(7408):486-90.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22810585
2012
Kachaner D, Filipe J, Laplantine E, Bauch A, Bennett KL, Superti-Furga G, Israël A, Weil R. Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression, Mol. Cell. 45, 553-66.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22365832
2012
Hopkins S, Linderoth E, Hantschel O, Suarez-Henriques P, Pilia G, Kendrick H, Smalley MJ, Superti-Furga G, Ferby I. Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis. Dev Cell. 2012 Sep 11;23(3):547-59.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22975324
2012
Hantschel O, Warsch W, Eckelhart E, Kaupe I, Grebien F, Wagner KU, Superti-Furga G, Sexl V. BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nat Chem Biol. 2012 Jan 29;8(3):285-93.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22286129
2012
Hantschel O, Superti-Furga G. Cell biology: a key driver of therapeutic innovation. J Cell Biol. 2012 Nov 12;199(4):571-5.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23148230
2012
Hantschel O, Grebien F, Superti-Furga G. The growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABL. Cancer Res. 2012 Oct 1;72(19):4890-5.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23002203
2012
Goncalves A, Karayel E, Rice GI, Bennett KL, Crow YJ, Superti-Furga G, Bürckstümmer T. SAMHD1 is a nucleic acid-binding protein that is mislocalised due to Aicardi-Goutières syndrome-associated mutations. Human Mut. 2012 Jul;33(7):1116-22.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22461318
2011
Winter GE, Rix U, Lissat A, Stukalov A, Mullner MK, Bennett KL, Colinge J, Nijman SM, Kubicek S, Kovar H, Kontny U, Superti-Furga G. An integrated chemical biology approach identifies specific vulnerability of Ewing’s sarcoma to combined inhibition of Aurora kinases A and B. Mol Cancer Ther. 2011 Oct;10(10):1846-56.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21768330
2011
Pichlmair A, Lassnig C, Eberle CA, Gorna MW, Baumann CL, Burkard TR, Burckstummer T, Stefanovic A, Krieger S, Bennett KL, Rulicke T, Weber F, Colinge J, Muller M, Superti-Furga G. IFIT1 is an antiviral protein that recognizes 5’-triphosphate RNA. Nat Immunol. 2011 Jul;12(7):624-30.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21642987
2011
Huber K, Superti-Furga G. After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders. Bioorg Med Chem. 2011 Jun 15;19(12):3616-24.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21306906
2011
Hantschel O, Grebien F, Superti-Furga G. Targeting allosteric regulatory modules in oncoproteins: “drugging the undruggable”. Oncotarget. 2011 Nov;2(11):828-9.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22084171
2011
Grebien F, Hantschel O, Wojcik J, Kaupe I, Kovacic B, Wyrzucki AM, Gish GD, Cerny-Reiterer S, Koide A, Beug H, Pawson T, Valent P, Koide S, Superti-Furga G. Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell. 2011 Oct 14;147(2):306-19.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22000011
2011
Goncalves A, Burckstummer T, Dixit E, Scheicher R, Gorna MW, Karayel E, Sugar C, Stukalov A, Berg T, Kralovics R, Planyavsky M, Bennett KL, Colinge J, Superti-Furga G. Functional dissection of the TBK1 molecular network. PLoS One. 2011;6(9):e23971.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21931631
2011
Gleixner KV, Mayerhofer M, Cerny-Reiterer S, Hormann G, Rix U, Bennett KL, Hadzijusufovic E, Meyer RA, Pickl WF, Gotlib J, Horny HP, Reiter A, Mitterbauer-Hohendanner G, Superti-Furga G, Valent P. KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib. Blood. 2011 Aug 18;118(7):1885-98.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21680801
2010
Wojcik J, Hantschel O, Grebien F, Kaupe I, Bennett KL, Barkinge J, Jones RB, Koide A, Superti-Furga G, Koide S. A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat Struct Mol Biol. 2010 Apr;17(4):519-27. Epub 2010 Mar 28.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20357770
2010
Sherbenou DW, Hantschel O, Kaupe I, Willis S, Bumm T, Turaga LP, Lange T, Dao KH, Press RD, Druker BJ, Superti-Furga G, Deininger MW. BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib. Blood. 2010 Oct 28;116(17):3278-85. Epub 2010 Jun 2.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20519627
2010
Li J, Rix U, Fang B, Bai Y, Edwards A, Colinge J, Bennett KL, Gao J, Song L, Eschrich S, Superti-Furga G, Koomen J, Haura EB. A chemical and phosphoproteomic characterization of dasatinib action in lung cancer. Nat Chem Biol. 2010 Apr;6(4):291-9. Epub 2010 Feb 28.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20190765
2010
Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC. Peroxisomes are signaling platforms for antiviral innate immunity. Cell. 2010 May 14;141(4): 668-81. Epub 2010 May 6.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20451243
2010
Colinge J, Rix U, Superti-Furga G. Novel global network scores to analyze kinase inhibitor profiles. 2010 Sep 9, ORSC & APORC, 305-313. Lecture Notes;
2010
Bluml S, Binder NB, Niederreiter B, Polzer K, Hayer S, Tauber S, Schett G, Scheinecker C, Kollias G, Selzer E, Bilban M, Smolen JS, Superti-Furga G, Redlich K. Anti-inflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis. Arthritis Rheum. 2010 Jun;62(6):1608-19.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20155834
2010
Baumann CL, Aspalter IM, Sharif O, Pichlmair A, Bluml S, Grebien F, Bruckner M, Pasierbek P, Aumayr K, Planyavsky M, Bennett KL, Colinge J, Knapp S, Superti-Furga G. CD14 is a co-receptor of Toll-like receptors 7 and 9. J Exp Med. 2010 Nov 22;207(12):2689-701. Epub 2010 Nov 15.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21078886
2009
Winger JA, Hantschel O, Superti-Furga G, Kuriyan J. The structure of the leukemia drug imatinib bound to human quinine reductase 2 (NQO2). BMC Struct Biol, 2009 Feb;9:7.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19236722
2009
Superti-Furga G. A biomedical adventurers’ guide to navigating between careers in academia and industry. Nat Rev Mol Cell Biol, 2009 Dec;10(12):884-7.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19859061
2009
Sillaber C, Herrmann H, Bennett K, Rix U, Baumgartner C, Böhm A, Herndlhofer S, Tschachler E, Superti-Furga G, Jäger U, Valent P. Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily. Eur J Clin Invest, 2009 Dec;39(12): 1098-109.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19744184
2009
Rix U, Superti-Furga G. Target profiling of small molecules by chemical proteomics. Nat Chem Biol, 2009 Sep;5(9):616-24.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19690537
2009
Rix U, Remsing Rix LL, Terker AS, Fernbach NV, Hantschel O, Planyavsky M, Breitwieser FP, Herrmann H, Colinge J, Bennett KL, Augustin M, Till JH, Heinrich MC, Valent P, Superti-Furga G. A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profifiling and chemical proteomics in chronic myeloid leukemia cells. Leukemia, Epub 2009 Nov 5.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19890374
2009
Remsing Rix LL, Rix U, Colinge J, Hantschel O, Bennett KL, Stranzl T, Müller A, Baumgartner C, Valent P, Augustin M, Till JH, Superti-Furga G. Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells. Leukemia, 2009 Mar;23(3):477-85.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19039322
2009
Pichlmair A, Schulz O, Tan CP, Rehwinkel J, Kato H, Takeuchi O, Akira S, Way M, Schiavo G, Reis e Sousa C. Activation of MDA5 requires higher-order RNA structures generated during virus infection. J Virol, 2009 Oct;83(20):10761-9. Epub 2009 Aug 5.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19656871
2009
Karayel E, Bürckstümmer T, Weitzer S, Martinez J, Superti-Furga G. The TLR independent DNA recognition pathway in murine macrophages: Ligand features and molecular signature. Eur J Immunol, 2009 Jul;39(7):1929-36.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19551900
2009
Habjan M, Pichlmair A, Elliott RM, Overby AK, Glatter T, Gstaiger M, Superti-Furga G, Unger H, Weber F. NSs protein of rift valley fever virus induces the specific degradation of the double stranded RNA-dependent protein kinase. J Virol, 2009 May;83(9):4365-75. Epub 2009 Feb 11.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19211744
2009
Fernbach NV, Planyavsky M, Müller A, Breitwieser FP, Colinge J, Rix U, Bennett KL. Acid elution and one-dimensional shotgun analysis on an orbitrap mass spectrometer – an application to drug affifinity chromatography. J 2009 Oct;8(10):4753-65.Proteome Res,.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19653696
2009
Bürckstümmer T, Baumann C, Blüml S, Dixit E, Dürnberger G, Jahn H, Planyavsky M, Bilban M, Colinge J, Bennett KL, Superti-Furga G. An orthogonal proteomic-genomic screen identififies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol, 2009 Mar;10(3):266-72. Epub 2009 Jan 21.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19158679
2009
Brehme M. Intercell – accelerating innovation. N Biotechnol, 2009 Apr;25(4):181-4. Epub 2009 Feb 21.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19429533
2009
Brehme M, Hantschel O, Colinge J, Kaupe I, Planyavsky M, Köcher T, Mechtler K, Bennett KL, Superti-Furga G. Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci USA, 2009 May 5;106(18): 7414-9. Epub 2009 Apr 20.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19380743
2009
Aebersold R, Auffray C, ..., Superti-Furga G, et al. Report on EU-USA workshop: how systems biology can advance cancer research. Mol Oncol, 2009 Feb;3(1):9-17.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19383362
2008
Superti-Furga G, Wieland F, Cesareni G. Finally: The digital, democratic age of scientific abstracts. FEBS Lett., 2008 Apr 9;582(8):1169.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18328821
2008
Soulat D, Bürckstümmer T, Westermayer S, Goncalves A, Bauch A, Stefanovic A, Hantschel O, Bennett KL, Decker T, Superti-Furga G. The DEAD-box helicase DDX3 is a TBK1 substrate required for IFN-beta production. EMBO J, 2008 Aug 6;27(15):2135–46.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18583960
2008
Sherbenou DW, Hantschel O, Turaga L, Kaupe I, Willis S, Bumm T, Press RD, Superti-Furga G, Druker BJ, Deininger MW. Characterization of BCR-ABL deletion mutants from patients with chronic myeloid leukemia. Leukemia, 2008 Jun;22(6):1184–90.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18354488
2008
Kneidinger M, Schmidt U, Rix U, Gleixner KV, Vales A, Baumgartner C, Lupinek C, Weghofer M, Bennett KL, Herrmann H, Schebesta A, Thomas WR, Vrtala S, Valenta R, Lee FY, Ellmeier W, Superti-Furga G, Valent P. The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood, 2008 Jan 7; PMID: 18180381.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18180381
2008
Henney A, Superti-Furga G. A network solution. Nature, 2008 Oct 9;455(7214):730–1.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18843342
2008
Hantschel O, Rix U, Superti-Furga G. Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib. Leuk Lymphoma, 2008 Apr;49(4):615-9. Review.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18398720
2008
Hantschel O, Gstoettenbauer A, Colinge J, Kaupe I, Bilban M, Burkard TR, Valent P, Superti-Furga G. The chemokine IL-8 and the surface activation protein CD69 are markers for Bcr-Abl activity in CML. Molecular Oncology, Vol 2/Issue3/ October 2008, 272–281.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19383348
2008
Filippakopoulos P, Kofler M, Hantschel O, Gish GD, Grebien F, Salah E, Neudecker P, Kay LE, Turk BE, Superti-Furga G, Pawson T, Knapp S. Structural coupling of Fes and Abl SH2-tyrosine kinase domains links substrate recognition and kinase activation. Cell. 2008 Sep 5;134(5): 793–803.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18775312
2008
Eggert US, Superti-Furga G. Drugs in Action. Nature Chem Biol, 2008 4(1):7–11.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18084271
2008
De Keersmaecker K, Versele M, Cools J, Superti-Furga G, Hantschel O. Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCRABL1 fusion protein kinases. Leukemia. 2008, Dec;22(12):2208–16.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18784740
2008
Bürckstümmer T, Bennett KL. Analysis of cellular protein complexes by affinity purification and mass spectrometry. In Proteomics Methods Express 2008 (O’Connor CD and Hames BD, eds.), pp 119–134, Scion, Oxfordshire.
2008
Baumgartner C, Gleixner KV, Peter B, Ferenc V, Gruze A, Remsing Rix LL, Bennett KL, Samorapoompichit P, Lee FY, Pickl WF, Esterbauer H, Sillaber C, Superti-Furga G, Valent P. Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1–PDGFRalpha. Exp Hematol, 2008 Oct;36(10):1244–53.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18619723
2007
Schuster C, Fernbach N, Rix U, Superti-Furga G, Holy M, Freissmuth M, Sitte HH, Sexl V. Selective serotonin reuptake inhibitors – A new modality for the treatment of lymphoma/leukaemia? Biochem Pharmacol. 2007, 74(9):1424–35.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/17709099
2007
Rix U, Hantschel O, Dürnberger G, Remsing Rix LL, Planyavsky M, Fernbach NV, Kaupe I, Bennett KL, Valent P, Colinge J, Köcher T, Superti-Furga G. Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib reveal novel kinase and non-kinase targets. Blood. 2007, 110:4055–4063.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/17720881
2007
Orchard S, Salwinski L, Kerrien S, Montecchi- Palazzi L, Oesterheld M, Stumpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, Salama JJ, Moore S, Wojcik J, Bader GD, Vidal M, Cusick ME, Gerstein M, Gavin AC, Superti-Furga G, et al. The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol. 2007, 25(8):894–8.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/17687370
2007
Kocher T, Superti-Furga G. Mass spectrometry-based functional proteomics: from molecular machines to protein networks. Nat Methods. 2007, 4(10):807–15.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/17901870
2007
Hantschel O, Rix U, Schmidt U, Burckstummer T, Kneidinger M, Schutze G, Colinge J, Bennett KL, Ellmeier W, Valent P, Superti-Furga G. The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc Natl Acad Sci USA. 2007, 104:13283–13288.
Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940229/